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The flask was then heated to 60 °C under 10 ATM of carbon monoxide and let stir for 3 h until all 9-iodo minocycline was consumed and a peak for the corresponding N-hydroxysuccinimide-ester intermediate (M+1 = 599) was formed as determined via LC/MS? I’m hoping the same high-grade blog post from you in the upcoming as well!
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